The use of low tidal volumes is a standard of care supported by a wide body of evidence that has demonstrated the efficacy of this intervention for saving the lives of patients with acute respiratory distress syndrome (ARDS) and mild ARDS (formerly acute lung injury). The ideal ventilator strategy for intensive care unit patients without […]

Strategies to reduce excessive sedation, including protocol implementation, have been shown to reduce length of stay and improve morbidity and mortality rates for critically ill patients. While intuitively appealing, the results of some clinical trials in this area have been inconsistent. In the October issue of The Journal of the American Medical Association, investigators from […]

Despite relative scarce evidence to support their use, intra-aortic balloon pumps (IABPs) have received high-grade recommendations in both U.S. and European guidelines for use in the management of cardiogenic shock. In the October issue of The New England Journal of Medicine, Holger Thiele, MD, and the IABP-SHOCK II trial investigators conducted a controlled study to […]

The Normoglycemia in Intensive Care Evaluation-Survival Using Glucose Algorithm Regulation (NICE-SUGAR) trial recruited 6,104 intensive care unit (ICU) patients in 24 hospitals. In this post hoc analysis of the trial’s database, the NICE-SUGAR investigators explored the association between different levels of hypoglycemia and death. Findings were published in the September 20 issue of The New […]

Induced hypertension, hypervolemia and hemodilution (triple-H) therapy has historically been considered to be beneficial for the treatment of vasospasm in patients with non-traumatic subarachnoid hemorrhage (SAH). In the October issue of Neurocritical Care, Martini and colleagues from the Oregon Health and Science University and University of Washington sought to determine the association between early fluid […]

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