Several studies have demonstrated improved outcomes when intensive care units (ICUs) are staffed by intensivists. Data supporting the benefits of 24-hour intensivist staffing have been inconsistent, with most studies hailing from single centers. In the May issue of The New England Journal of Medicine, researchers from the University of Pittsburgh School of Medicine in Pennsylvania […]

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Extracorporeal membrane oxygenation (ECMO) for support of adult patients with acute lung failure has been a vigorously debated topic among critical care professionals. As researchers continue to investigate its risks and benefits, indications for use are slowly expanding. Increasing wait times for lung transplants and the poor outcomes associated with endotracheal intubation warrant new support […]

Results of the PROWESS-SHOCK trial, as well as a 2012 Cochrane review, seem to have resolved the controversy related to efficacy of recombinant human activated protein C (rhAPC). However, discussion continues, as the May issue of Critical Care Medicine examines observational data from the Surviving Sepsis Campaign to analyze the association between treatment with rhAPC […]

Sedation in intensive care unit (ICU) patients is assumed to facilitate proper care with improved patient comfort and safety, though long-term use is fraught with potential serious adverse effects. The use of dexmedetomidine, a sedative with alpha-2 agonist properties, may enhance patient safety and comfort in long-term sedation, but evidence has been limited and inconclusive. […]

For more than 40 years, epinephrine has been regarded as a standard of care in advanced cardiac life support. In the March 21 issue of The Journal of the American Medical Association, Hagihara et al performed the largest prospective, nonrandomized observational study to date to determine how epinephrine use in cardiopulmonary resuscitation before hospital arrival was […]

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