Permissive hypercapnia is a well-accepted ventilator strategy for the management of acute respiratory distress syndrome as well as other causes of respiratory failure, such as the respiratory distress syndrome seen in premature infants.  Multiple studies have demonstrated that both myocardial contractility and systemic vascular resistance (SVR) decrease with hypercapnic acidosis, the ultimate effect being that […]

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Observational and qualitative studies have suggested positive benefits associated with family presence during cardiopulmonary resuscitation (CPR). Family presence may help alleviate the emotional burden and improve the bereavement process. Concerns about interference with resuscitative efforts and medicolegal ramifications have yet to be answered in rigorously designed studies. Patricia Jabre and colleagues in France conducted a […]

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Although anemia may cause an increase in morbidity and mortality rates in critically ill pediatric patients, transfusion of packed red blood cells (pRBCs) carries significant risks, which have also been demonstrated in pediatric cardiac surgery patients. However, studies related to these risks have had problems with confounding and the use of pRBCs that were not […]

  • Comments Off on What Are the Risks in Pediatric RBC Transfusion?

Ventilator-associated pneumonia (VAP) is an important complication in intensive care unit (ICU) patients. Current guidelines in the United States strongly recommend that surveillance be conducted for bacterial pneumonia in ICU patients, but diagnostic criteria have been criticized for the lack of sensitivity and specificity, especially regarding multidrug-resistant (MDR) pathogens. Brusselaers and investigators from Ghent University […]

  • Comments Off on Can Respiratory Tract Cultures Predict VAP?

Up to 25% of intensive care unit (ICU) patients may have gastrointestinal bleeding when stress ulcer prophylaxis is not administered. In a systematic review and meta-analysis by Alhazzani et al, the effect of proton pump inhibitors (PPI) versus histamine 2 receptor antagonists (H2RA) on the prevention of clinically important gastrointestinal bleeding was investigated. Their results […]

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